BitLocker pins the encryption key to TPM and to a hardware profile that includes the motherboard, CPU, and boot configuration. If you change too many identifiers at once, BitLocker will demand the recovery key on next boot.
Step one: export the recovery key BEFORE you start. In Windows, run manage-bde -protectors -get C: to see it, or pull it from your Microsoft account. Without that key, you'll lose access to the data.
If you're changing only software-level identifiers (machine GUID, volume ID, MAC), BitLocker won't notice. The chain of trust runs through TPM, which our changer doesn't touch.
If you want to change SMBIOS too — temporarily suspend BitLocker (manage-bde -protectors -disable C:), perform the HWID change, then re-enable it. BitLocker will rebind itself to the new profile without re-encrypting the disk.
Pro tip: keep BitLocker recovery keys in a password manager (1Password, Bitwarden). It costs nothing to maintain and saves you from "my disk won't boot" panic at the worst possible moment.